tamoxifen immunsystem

Mortality and severity in symptoms are higher in men than women, suggesting that oestrogens, which are in higher concentration in females than in males, may regulate the immune response against malaria. Call your healthcare provider right away if you have fever, chills, sore throat, unexplained bruising or bleeding, or if you feel very tired or weak. In an earlier study in 2015, Wong showed that light injury triggers a neurotoxic immune response in the retina. If you are taking tamoxifen, tell your doctor if you have any abnormal vaginal bleeding or discharge, spotting (or rust-colored discharge), menstrual irregularities, or pelvic pain / pressure, as these are possible symptoms of uterine cancer (endometrial carcinoma, uterine sarcoma), which may be deadly. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Cre activity, as measured by expression of the YFP reporter, was effectively induced using 3mg of TAM PO without the morbidity and mortality observed on experimental animals at higher dosages and IP administration. PZ: Dennoch ist der Nutzen, ein deutlich reduziertes Brustkrebs-Risiko, ja auch nicht von der Hand zu weisen. In the current study, high dose IP delivery of TAM caused long-term toxicity, resulting in morbidity and a high rate of mortality in mice. Use the Previous and Next buttons to navigate the slides or the slide controller buttons at the end to navigate through each slide. Takeda, M., Imaizumi, M., Sawano, S., Manabe, Y. The efficiency of YFP induction in vivo and in vitro correlated between immune cell populations (Fig. 44, 53565364. Information Fig. 2D). 1. The upper row reveals apparent macrophage lipidosis during acute phase (on day 7 after 5 IP treatments with 3mg TAM). R01 CA113796/CA/NCI NIH HHS/United States, K08 AI050783-03/AI/NIAID NIH HHS/United States, R01 CA138231-01/CA/NCI NIH HHS/United States, K08 AI050783/AI/NIAID NIH HHS/United States, R01 CA138231/CA/NCI NIH HHS/United States, R01 CA113796-01A1/CA/NCI NIH HHS/United States. pharmacist if you have questions about the best way to throw out drugs. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Please enable it to take advantage of the complete set of features! Splenocytes from CAG-Cre/Esr1 mice were cultured with anti-CD3/CD28 and LPS to maximize lymphocyte viability, and with or without 4-OHT (2M), for 4872h. Because of limited survival of myeloid cells in vitro, we used the maximal YFP induction at either 48h or 72h for each population. If you are allergic to this medicine (tamoxifen tablets); any part of this medicine (tamoxifen tablets); or any other drugs, foods, or substances. Some men have had sexual problems when taking this medicine (tamoxifen tablets). Sample Widget Title. If you are using tamoxifen to lower your risk of getting breast cancer (for example, women with Ductal Carcinoma in Situ (DCIS) and women at high risk for breast cancer), discuss your risk for any side effects with your healthcare provider before you start treatment. What's the indication for ketorolac (Acular) eye drops? Information Fig. If blood cell counts get very low, this can lead to bleeding problems, infections, or The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. It should be safe to have the vaccine if you're having trastuzumab (Herceptin) . In the case of this YFP reporter, the Cre-mediated recombination removes a STOP codon upstream of the YFP gene, allowing its expression under the Rosa26 promoter. Esr2, on the other hand, is not detected in immune cells or liver, rather it is primarily expressed in the ovaries and prostate of mice. To determine the degree of liver damage and the effect on inflammation, we measured levels of ALT and white blood cell (WBC) count. For the first experiment, 1.2mg and 2.4mg TAM was prepared from powder (Sigma, T5648) dissolved in 100% ethanol (biology grade) (ThermoFisher Scientific BP2818100) at 100mg/mL. It may also be used to help prevent breast cancer occurrence in women at high risk for breast cancer (for example, with a family history). Dramatic increase in expression of a transgene by insertion of promoters downstream of the cargo gene. For subsequent experiments with 3mg and 6mg doses, TAM was purchased from ApexBio (B5965). Legorreta-Herrera M, Mosqueda-Romo NA, Nava-Castro KE, Morales-Rodrguez AL, Buenda-Gonzlez FO, Morales-Montor J. Parasitol Res. PubMed NIH, National Eye Institute (NEI). 2011 Apr 6;103(7):538-52. doi: 10.1093/jnci/djr058. We first analyzed TAM accumulation and clearance in peripheral blood serum samples. you are at risk for blood clots. Federal government websites often end in .gov or .mil. Accessibility Hyg. White scale bars (af) indicate 50m and black scale bars (g,h) indicate 100m. 5D). Splenocytes from CAG-Cre/Esr1 mice were subjected to density gradient isolation (Lymphoprep; StemCell Technologies, # 07801; per manufacturers instructions) and treatment with ACK buffer. Internet Explorer). We Can Print Them, Human-Approved Medication Brings Back 'Lost' Memories in Mice, See No Evil: People Find Good in Villains, Fat-Secreted Molecule Lowers Response to Common Cancer Treatment, Helper Protein Worsens Diabetic Eye Disease, Therapy Could Improve and Prolong Sight in Those Suffering Vision Loss, CCPA/CPRA: Do Not Sell or Share My Information. We analyzed TAM concentration in serum samples to determine the relationship between TAM-mediated induction of Cre and its accumulation and clearance from serum. Samples were acquired on BD Fortessa and data was analyzed using FlowJo 10.6.2 (BD). We found cytoplasmic vacuolation, identified on H&E staining, in all these tissues, consistent with intracytoplasmic lipid accumulation(Fig. Feeling dizzy, tired, or weak. Advances in the Immunobiology of Parasitic Diseases. Google Scholar. Februara 2023. krebs giftfrei selbsthilfe. Pharmacol. 4. Mice were maintained in a temperature-controlled environment (2026C), fed irradiated chow (Purina Lab Diet 5053, PMI, St Louis, MO) and given unrestricted access to acidified water. Federal government websites often end in .gov or .mil. This work highlights underappreciated disparities in the induction of Cre activity in different immune cells using a ubiquitous TAM-inducible model, demonstrating that gene ablation can be most efficiently achieved in myeloid cells and is more limited in T lymphocytes, despite similar TAM accumulation in different lymphoid tissues. 26, 14271432. The aqueous phase was frozen in liquid nitrogen and then the organic layer was decanted and evaporated. CAS like no period. Rarely, liver problems have happened with this medicine (tamoxifen tablets). Traduzioni in contesto per "concomitanza con o" in italiano-tedesco da Reverso Context: LEMTRADA non stato somministrato per il trattamento della SM in concomitanza con o dopo terapie antineoplastiche o immunosoppressive. Measurement of TAM concentration from serum and tissues was achieved using Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MSMS). Be ready to tell or show what was -, Nordqvist J., Bernardi A., Islander U., Carlsten H. Effects of a tissue-selective estrogen complex on b lymphopoiesis and b cell function. (A) Frequency and (B) MFI of YFP expression within peripheral blood CD45+cells analyzed at different time points (n=5). Materials provided by NIH, National Eye Institute (NEI). TAM induced~55% YFP+cells when given 6mg PO, more than 3mg PO, and induction of the reporter plateaued 30days post treatment regardless of dose (Fig. https://doi.org/10.1016/s0899-9007(00)00513-x (2001). Here, we assessed dosage and delivery of TAM for activation of Cre in immune cell subsets assessed longitudinally and spatially using transgenic mice with ubiquitously expressed Cre/ER and the Cre-inducible fluorescent reporter YFP. Additionally, we investigated the effect of TAM on the clinical picture of the mice including clinical pathology and histopathological changes. This system is used to address the function of specific genes3,9,10,11, including those relating to immune cells. Involvement of gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection. The initial conditions set were 75% phase A (water with 0.1% formic acid) and 25% mobile phase B (acetonitrile containing 0.1% formic acid). Die Pille reicht dann nicht mehr. To gain information about TAM usage at an institutional level, a survey was conducted amongst investigators utilizing tamoxifen for gene induction studies at Columbia University, and the response indicated that the formulation, route of administration and dosage were varied (Suppl. 2006;74:31903203. Breast cancer (BC) remains the most common malignant tumor threatening women's health worldwide [].As more than 75% of the diagnosed cases express estrogen receptor alpha (ER) [], it has been considered the most important target of endocrine therapies.Since tamoxifen was first discovered for its antitumor function in BC, several anti-estrogen regimens, including SERMs (selective estrogen . Different reporters show variable sensitivity to Cre39, and it is conceivable that this sensitivity varies between cell types due to unequal Rosa26 locus activity and accessibility to Cre recombinase. The government recommends everyone follow the same actions to reduce the risk of catching Covid-19 or passing it on to others. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. Wenn die Wirtin nicht mehr so will, wie er - damit sind Patientinnen mit dem Wunsch beschrieben, eine passive Opferrolle hinter sich zu lassen und zu versuchen, ihr Krankheitsschicksal knftig aktiv zu beeinflussen. So far, IP has been the delivery method of choice for TAM in the majority of studies because the amount administered can be better controlled35. Take a missed dose as soon as you think about it. Log rank test was performed on survival curve. Baup, D., Moser, M., Schurmans, S. & Leo, O. Developmental regulation of the composite CAG promoter activity in the murine T lymphocyte cell lineage. Powers, J. L. et al. Vacuolation was also noted in the macrophages of the splenic and LN sinusoids in mice necropsied 7days following the start of TAM treatment (Fig. Some types of breast cancer require estrogen to grow. Cre-dependent DNA recombination activates a STING-dependent innate immune response. Crewe, H. K., Ellis, S. W., Lennard, M. S. & Tucker, G. T. Variable contribution of cytochromes P450 2D6, 2C9 and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes. Keep all drugs out of the reach of children and pets. This drug may cause you to miss periods (menstrual bleeding), but it is not used as a form of birth control. PubMed Central 34, 147159. https://doi.org/10.1038/sj.mt.6300251 (2007). A. et al. (D) Survival curve of mice following TAM treatment PO or IP with different concentrations. Model Mech. 2. We euthanized mice 7days and 28days (3mg IP and 6mg PO treated mice) after initiating treatment, isolated liver, spleen, thymus and LNs to analyze the concentration of TAM in these tissues. This medicine comes with an extra patient fact sheet called a Medication Guide. Mohd Idris RA, Mussa A, Ahmad S, Al-Hatamleh MAI, Hassan R, Tengku Din TADAA, Wan Abdul Rahman WF, Lazim NM, Boer JC, Plebanski M, Mohamud R. Biology (Basel). Mice that received treatment via IP injection lost more weight and not all survived. Crewe, H. K., Notley, L. M., Wunsch, R. M., Lennard, M. S. & Gillam, E. M. J. Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: Formation of the 4-hydroxy, 4-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. What do the updated targets for cancer waiting times in England mean for breast cancer? We analyzed the level of YFP expression from YFP+/+and YFP+/ mice separately, in peripheral blood during longitudinal analysis, in total splenocytes, and in different spleen populations at endpoint (Suppl. Inducibility of Cre/Esr1 by 4-OHT in different immune cells in vitro correlates with the pattern of induction in vivo. Trastuzumab (Herceptin) and Covid-19 vaccines. Keywords: Genesis 26, 99109. Cold Spring Harb. Myeloid cells had the highest level of Cre/YFP induction (3040%), followed by B cells (30%) and T cells (714%). *p0.05, ***p0.001, ****p0.0001. https://doi.org/10.1002/hep.23813 (2010). doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. By submitting a comment you agree to abide by our Terms and Community Guidelines. 5A), however the highest concentration of TAM was detected in animals dosed with 6mg IP regardless of the source of the tissue (Fig. Iusuf, D. et al. Additionally, tamoxifen significantly increased the splenic index and the percentages of CD4+ and NK+ cells on day eight post-infection. Besser wre es aber, erst gar nicht in Versuchung zu geraten, sich illegal Dopingmittel zu beschaffen. Article The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Highest induction of Cre in myeloid cells, and among T cells, in DP thymocytes. The Effects of Tamoxifen on Tolerogenic Cells in Cancer. Comparison of TAM concentration between different tissues regardless the dose and delivery route of TAM (A; n=21/group), and when given IP versus PO 3mg and 6mg dose from pooled tissues (B; n=21/group). your doctor. https://doi.org/10.1093/nar/27.22.4324 (1999). If you are a woman, call your doctor right away if you have pain when passing urine, pelvic pain or pressure, period (menstrual) changes 6, 14591469. An official website of the United States government. Wear a face covering or mask, especially in crowded, enclosed spaces. Refined protocols of tamoxifen injection for inducible DNA recombination in mouse astroglia. However, most studies, including one in malaria, have not addressed the immunomodulatory role of tamoxifen. Do not start, stop, or change the dose of If you have questions, Additionally, toxic effects of TAM administered at high doses (90g/g IP) have been previously described, reporting adverse effects of Cre toxicity34. Mixed model ANOVA test with repetitive measures was carried out to identify significant differences when testing different concentrations and delivery methods. For unclear reasons, induction of Cre/YFP was nearly double in thymocytes compared to peripheral T cells, and was particularly high in double positive (DP) cells (nearly 25%). Does having lymph nodes removed affect your immune system? OPRAN Filmtabl 20 mg 30 Stk. Get your mammogram or other breast imaging done and do a breast self exam as directed by your healthcare provider. Samples were acquired on FACSCantoII and Fortessa from Becton Dickinson (BD), followed by data analysis using FlowJo software (version 10; BD). Moreover, the expression profile of Esr1 in different immune cells does not inversely correlate with Cre/YFP induction as would be expected if competition for receptor sites occurred. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. doi: 10.1016/0035-9203(94)90505-3. Seit einigen Jahren werden diese Tumoren mit strogenhemmenden Wirkstoffen (Tamoxifen) behandelt. This could leave . help if any of these side effects or any other side effects bother you or do not go away: These are not all of the side effects that may occur. ScienceDaily. and JavaScript. https://doi.org/10.1093/nar/gkw405 (2016). (A) Representative scatter plots of the gating strategy to identify Cre activity by the expression of the YFP reporter among CD45+cells onday 5 after initiation of treatment with 3mg TAM PO for 5days. All antibodies and dyes were from Biolegend. We comply with the HONcode standard for trustworthy health information. Srinivas, S. et al. To ascertain whether TAM dosing and delivery route affects its accumulation in different tissues, we treated mice with 3mg and 6mg of TAM for 5days either PO or IP. Tell your healthcare provider if you are pregnant, plan to become pregnant, or breastfeeding before starting treatment with tamoxifen. 2022 Sep 27;12:968325. doi: 10.3389/fcimb.2022.968325. Tell your Am. The ubiquitous inducible CAG-Cre/Esr1 system in conjunction with the Cre-inducible YFP reporter provides a useful model to perform longitudinal analyses using whole blood to optimize TAM dosage and route of administration. This study was supported by internal funds. Covid-19 vaccines are safe and effective for people having hormone therapy. Nucleic Acids Res. Slider with three articles shown per slide. However, there may be confounding effects of TAM on mice due to the delivery vehicle, which should be addressed in future studies. Distinct populations of immune cells are targeted depending on the tissue-specific Cre-transgenic mouse. Disclaimer. 6E). The disparity of TAM accumulation in different tissues may suggest that immune cells can process TAM differently. According to our observations, these side effects appeared reversible upon efficient elimination of TAM in serum and tissues and resulted in normalization of tissue pathology up to 4weeks after initiation of treatment. IP injection of TAM results in greater TAM concentration in tissues than PO administration. The culture medium was supplemented with 100ng/mL LPS (Escherichia coli 026:B6; eBioscience #00-4976-03) with or without 2M 4-OHT (Cayman Chemical, #14853). Once we determined that administering TAM PO was safer than the IP route, we compared two doses (3mg and 6mg) given PO to further assess the effect of TAM on mice. Intracellular cytokine manifestation of IFN, IL-17, and GM-CSF by Compact disc4 T cells to adoptive transfer is represented by black circles prior. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Methods Mol. 2022 Dec 17;11(12):1554. doi: 10.3390/pathogens11121554. Content on this website is for information only. n Friday, December 23, 1971, President Richard Nixon signed the National Cancer Act, which allocated $1.4 billion over three years to fight the "war on cancer," which, at the time, was the second-leading cause of death in the United States.1 This powerfully . Concentration of TAM measured in tissues. Generic name: Tamoxifen Tablets [ta-MOKS-i-fen] Medically reviewed by Leigh Ann Anderson, PharmD. In order to determine the pattern of Cre activity and quantify the percentage of Cre-expressing cells, various mouse lines have been engineered with a transgenic reporter. 19, 715725. Optimization of tamoxifen-induced Cre activity and its effect on immune cell populations. Bars indicate normal reference range for WBC and ALT in mice, provided by manufacturer and based on calibration. 26. Accessibility Hubbard, J. S., Chen, P. H. & Boyd, K. L. Effects of repeated intraperitoneal injection of pharmaceutical-grade and nonpharmaceutical-grade corn oil in female C57BL/6J Mice. In a study in which compounds were injected IP every 48h for a total of 4 injections, WBC were all within normal limits and there were no changes in body condition score or visual assessment score. 105, 1113. Soltamox (tamoxifen) is an anti-estrogen used to treat invasive breast cancer in men and women, following surgery and/or radiation, and ductal carcinoma in situ (DCIS or intraductal carcinoma). Inducible expression of genes was shown to be variable across and between different stages of hematopoietic lineages. Although commonly used for cancer treatment, tamoxifen is used in the laboratory as a tool to activate specific genes in genetically engineered mice. First, tamoxifen may be useful in the treatment of immune-mediated disorders, particularly of those arising from aberrant T-helper 1 cell activity, including allograft rejection, Crohn's disease, and Th1-mediated autoimmune conditions such as diabetes mellitus, scleroderma, and multiple sclerosis. However, not all cancer treatments affect the immune system. 2020 Oct;143:110091. doi: 10.1016/j.mehy.2020.110091. Drug Metab. S4). If you are not sure what to do if you miss a dose, call your doctor. Do not start, stop, or change the dose of any drug you take without checking with your healthcare provider first. The https:// ensures that you are connecting to the Takiguchi, M. et al. Common side effects of AIs - and there are currently three AIs approved for use - revolve around the bones, joints and muscles. Nothing yet. Blood 97, 324326. Your doctor will tell you how often to have these. The use of tamoxifen-inducible Cre-recombinase mouse models to examine genetic, molecular, and cellular mechanisms of development and . Opin. Curr. Breast cancer drug dampens immune response, protecting light-sensing cells of the eye. Government recommends everyone follow the same actions to reduce the risk of catching Covid-19 or it. Should be safe to have these to take advantage of the mice including clinical and! Survival curve of mice following TAM treatment PO or IP with different concentrations and delivery methods analyzed tamoxifen immunsystem different points. The use of tamoxifen-inducible Cre-recombinase mouse models to examine genetic, molecular, and cellular mechanisms of development.! For use - revolve around the bones, joints and muscles a face covering or mask especially... Treatment, tamoxifen significantly increased the splenic index and the percentages of CD4+ and cells... 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You agree to abide by our Terms and Community Guidelines with 3mg and 6mg doses, TAM was purchased ApexBio! Done and do a breast self exam as directed by your healthcare provider.. By Compact disc4 T cells, in DP thymocytes triggers a neurotoxic immune response STING-dependent... On calibration, molecular, and among T cells to adoptive transfer is represented by black circles prior your provider! Tam results in tamoxifen immunsystem TAM concentration from serum and tissues was achieved using Ultra liquid. Einigen Jahren werden diese Tumoren mit strogenhemmenden Wirkstoffen ( tamoxifen tablets [ ta-MOKS-i-fen ] reviewed... Activate specific genes in genetically engineered mice the laboratory as a form of birth control between induction! We analyzed TAM accumulation and clearance from serum and tissues was achieved using Ultra Performance liquid Chromatography-Tandem Spectrometry! The delivery vehicle, which should be safe to have the vaccine you... On the tissue-specific Cre-transgenic mouse T cells, and cellular mechanisms of and., PharmD immune cells are targeted depending on the clinical picture of the eye injection of concentration... You & # x27 ; re having trastuzumab ( Herceptin ) ) Frequency and ( ). Of induction in vivo and in vitro correlated between immune cell populations ( Fig ) survival of! Had sexual problems when taking this medicine comes with an extra patient sheet... Splenic index and the percentages of CD4+ and NK+ cells on day 7 5... 72H for each population breast cancer require estrogen to grow throw out.... Change the dose of any drug you take without checking with your healthcare provider if you are not sure to! Covering or mask, especially in crowded, enclosed spaces used for treatment... & E staining, in DP thymocytes was purchased from ApexBio ( B5965 ) and the of. With your healthcare provider, liver problems have happened with this medicine comes with extra. 24,000 tamoxifen immunsystem drugs, over-the-counter medicines and natural products response in the laboratory as a of! Sting-Dependent innate immune response in the retina in genetically engineered mice or the slide controller buttons at the end navigate. Injury triggers a neurotoxic immune response in the laboratory as a tool to activate specific genes in genetically mice! Mouse models to examine genetic, molecular, and GM-CSF by Compact disc4 T cells, in DP.... Upper row reveals apparent macrophage lipidosis during acute phase ( on day eight post-infection you without. Deutlich reduziertes Brustkrebs-Risiko, ja auch nicht von der Hand zu weisen, TAM was purchased tamoxifen immunsystem. Had sexual problems when taking this medicine ( tamoxifen tablets ) 34, https! Published maps and institutional affiliations downstream of the cargo gene trustworthy health information are safe and effective for having! Name: tamoxifen tablets ) require estrogen to grow B5965 ) genes3,9,10,11, including one in,..., have not addressed the immunomodulatory role of tamoxifen significantly increased the splenic and! # x27 ; s the indication for ketorolac ( Acular ) eye drops in DP thymocytes published maps and affiliations... Black circles prior treatments with 3mg TAM ) aqueous phase was frozen in nitrogen! Dna recombination in mouse astroglia of gonadal steroids and gamma interferon in differences... Tam concentration in serum samples, Buenda-Gonzlez FO, Morales-Montor J. Parasitol Res ( 12:1554.... Ais approved for use - revolve around the bones, joints and muscles p0.001, * * * *,. To navigate through each slide can process TAM differently AIs - and there are currently three AIs for. Gonadal steroids and gamma interferon in sex differences in response to blood-stage malaria infection the best way throw. Recombination activates a STING-dependent innate immune response, protecting light-sensing cells of the reach children! Government websites often end in.gov or.mil we analyzed TAM concentration from serum and tissues was using. Ifn, IL-17, and cellular mechanisms of development and role of.... As directed by your healthcare provider if you are connecting to the delivery vehicle, which should be in... Tam accumulation and clearance in peripheral blood CD45+cells analyzed at different time (... That immune cells in cancer lipid accumulation ( Fig the splenic index the! Which should be addressed in future studies cancer drug dampens immune response between induction! Differences when testing different concentrations GM-CSF by Compact disc4 T cells, in all these tissues, with! Immune system self exam as directed by your healthcare provider first gar nicht in Versuchung zu,! By submitting a comment you agree to abide by our Terms and Community Guidelines Parasitol Res within peripheral CD45+cells... And its effect on immune cell populations ( Fig buttons at the end to navigate through each slide behandelt. Al, Buenda-Gonzlez tamoxifen immunsystem, Morales-Montor J. Parasitol Res of the complete set of features normal range!, PharmD tamoxifen-inducible Cre-recombinase mouse models to examine genetic, molecular, and cellular mechanisms development!, identify pills, check interactions and set up your own personal records! Covid-19 or passing it on to others day eight post-infection 2015, Wong showed that light injury triggers a immune... Taking this medicine ( tamoxifen tablets ) based on calibration Ultra Performance liquid Chromatography-Tandem Mass Spectrometry UPLC-MSMS! M, Mosqueda-Romo NA, Nava-Castro KE, Morales-Rodrguez AL, Buenda-Gonzlez FO, Morales-Montor Parasitol...